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GWAS of Follicular ...
GWAS of Follicular Lymphoma Reveals Allelic Heterogeneity at 6p21.32 and Suggests Shared Genetic Susceptibility with Diffuse Large B-cell Lymphoma
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- Smedby, Karin E. (author)
- Karolinska Institutet
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Foo, Jia Nee (author)
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Skibola, Christine F. (author)
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show more...
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- Darabi, Hatef (author)
- Karolinska Institutet
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Conde, Lucia (author)
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- Hjalgrim, Henrik (author)
- Karolinska Institutet
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Kumar, Vikrant (author)
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Chang, Ellen T. (author)
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Rothman, Nathaniel (author)
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Cerhan, James R. (author)
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Brooks-Wilson, Angela R. (author)
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Rehnberg, Emil (author)
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Irwan, Ishak D. (author)
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- Ryder, Lars P. (author)
- Karolinska Institutet
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Brown, Peter N. (author)
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Bracci, Paige M. (author)
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Agana, Luz (author)
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Riby, Jacques (author)
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Cozen, Wendy (author)
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Davis, Scott (author)
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Hartge, Patricia (author)
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Morton, Lindsay M. (author)
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Severson, Richard K. (author)
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Wang, Sophia S. (author)
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Slager, Susan L. (author)
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Fredericksen, Zachary S. (author)
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Novak, Anne J. (author)
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Kay, Neil E. (author)
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Habermann, Thomas M. (author)
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Armstrong, Bruce (author)
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Kricker, Anne (author)
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Milliken, Sam (author)
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Purdue, Mark P. (author)
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Vajdic, Claire M. (author)
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Boyle, Peter (author)
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Lan, Qing (author)
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Zahm, Shelia H. (author)
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Zhang, Yawei (author)
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Zheng, Tongzhang (author)
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Leach, Stephen (author)
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Spinelli, John J. (author)
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Smith, Martyn T. (author)
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Chanock, Stephen J. (author)
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Padyukov, Leonid (author)
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- Alfredsson, Lars (author)
- Karolinska Institutet
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- Klareskog, Lars (author)
- Karolinska Institutet
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- Glimelius, Bengt (author)
- Uppsala universitet,Enheten för onkologi
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Melbye, Mads (author)
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Liu, Edison T. (author)
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Adami, Hans-Olov (author)
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- Humphreys, Keith (author)
- Karolinska Institutet
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Liu, Jianjun (author)
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(creator_code:org_t)
- 2011-04-21
- 2011
- English.
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In: PLoS Genetics. - : Public Library of Science (PLoS). - 1553-7390 .- 1553-7404. ; 7:4, s. e1001378-
- Related links:
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- Non-Hodgkin lymphoma (NHL) represents a diverse group of hematological malignancies, of which follicular lymphoma (FL) is a prevalent subtype. A previous genome-wide association study has established a marker, rs10484561 in the human leukocyte antigen (HLA) class II region on 6p21.32 associated with increased FL risk. Here, in a three-stage genome-wide association study, starting with a genome-wide scan of 379 FL cases and 791 controls followed by validation in 1,049 cases and 5,790 controls, we identified a second independent FL-associated locus on 6p21.32, rs2647012 (ORcombined = 0.64, P-combined= 2x10(-21)) located 962 bp away from rs10484561 (r(2)< 0.1 in controls). After mutual adjustment, the associations at the two SNPs remained genome-wide significant (rs2647012: ORadjusted = 0.70, P-adjusted= 4x10(-12); rs10484561: ORadjusted = 1.64, P-adjusted= 5x10(-15)). Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk. Moreover, in a follow-up analysis of the top 6 FL-associated SNPs in 4,449 cases of other NHL subtypes, rs10484561 was associated with risk of diffuse large B-cell lymphoma (ORcombined = 1.36, P-combined = 1.4x10(-7)). Our results reveal the presence of allelic heterogeneity within the HLA class II region influencing FL susceptibility and indicate a possible shared genetic etiology with diffuse large B-cell lymphoma. These findings suggest that the HLA class II region plays a complex yet important role in NHL.
Keyword
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
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Smedby, Karin E.
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Foo, Jia Nee
-
Skibola, Christi ...
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Darabi, Hatef
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Conde, Lucia
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Hjalgrim, Henrik
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show more...
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Kumar, Vikrant
-
Chang, Ellen T.
-
Rothman, Nathani ...
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Cerhan, James R.
-
Brooks-Wilson, A ...
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Rehnberg, Emil
-
Irwan, Ishak D.
-
Ryder, Lars P.
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Brown, Peter N.
-
Bracci, Paige M.
-
Agana, Luz
-
Riby, Jacques
-
Cozen, Wendy
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Davis, Scott
-
Hartge, Patricia
-
Morton, Lindsay ...
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Severson, Richar ...
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Wang, Sophia S.
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Slager, Susan L.
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Fredericksen, Za ...
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Novak, Anne J.
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Kay, Neil E.
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Habermann, Thoma ...
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Armstrong, Bruce
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Kricker, Anne
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Milliken, Sam
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Purdue, Mark P.
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Vajdic, Claire M ...
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Boyle, Peter
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Lan, Qing
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Zahm, Shelia H.
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Zhang, Yawei
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Zheng, Tongzhang
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Leach, Stephen
-
Spinelli, John J ...
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Smith, Martyn T.
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Chanock, Stephen ...
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Padyukov, Leonid
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Alfredsson, Lars
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Klareskog, Lars
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Glimelius, Bengt
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Melbye, Mads
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Liu, Edison T.
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Adami, Hans-Olov
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Humphreys, Keith
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Liu, Jianjun
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show less...
- Articles in the publication
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PLoS Genetics
- By the university
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Uppsala University
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Karolinska Institutet